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Event ID: 1310Source: ASP.NET 2.0.50727.0Exception message: Could not load file or assembly 'Microsoft.Exchange.Security, Version=14.0.0.0, Culture=neutral, PublicKeyToken=31bf3856ad364e35' or one of its dependencies. The system cannot find the file specified. (C:Program FilesMicrosoftExchange ServerV14ClientAccessAutodiscoverweb.config line 940) C:Program FilesMicrosoftExchange ServerV14ClientAccessAutodiscoverweb.configC:Program FilesMicrosoftExchange ServerV14ClientAccessPowerShellweb.configThe transport process couldn't load poison message information from the registry. Access to the registry failed with the following error: Access to the registry key 'HKEY_LOCAL_MACHINESOFTWAREMicrosoftExchangeServer14TransportPoisonMessageBootProcess' is denied.Administrators: Full ControlSystem: Full ControlNetwork Service: Full Controlhttp://technet.microsoft.com/en-us/library/ff360361(v=exchg.140).aspxThe Pickup directory doesn't have permissions to write the pickup location to registry (HKEY_LOCAL_MACHINESOFTWAREMicrosoftExchangeServer14Pickup). Please make sure Network Service has Full Control to the registry location. The error was System.UnauthorizedAccessException: Access to the registry key 'HKEY_LOCAL_MACHINESOFTWAREMicrosoftExchangeServer14Pickup' is denied.Ran a Health Check with exbpa'ClientAccessRole' not configured'HubTransportRole' not configuredEnded up with System Center Endpoint Protection being the issue. Added %ProgramFiles%MicrosoftExchange Server in the exclusion list.