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After updating to DPM 2012 R2 the DPMDB says Agent unreachable in the Protection area in DPM. Looking in the Event Viewer - System Log, there is the following two error messages:

 

Source: DistributedCOM

Event ID: 10005

DCOM got error "1053" attempting to start the service DPMRA with arguments "Unavailable" in order to run the server: {DA6AA17A-D61C-4E9C-8CEA-DB25DEA52A95}

 

Source: Service Control Manager

Event ID: 7009

A timeout was reached (30000 milliseconds) while waiting for the DPMRA service to connect.

 

If you try to start DPMRA.exe manually in a command prompt it says that VssRequestor.dll is missing. After copying this file from another server (C:\Program Files\Microsoft Data Protection Manager\DPM\bin\VssRequestor.dll) to C:\Program Files\Microsoft System Center 2012\DPM\DPM\bin the DPMRA starts successfully.

 

Source: http://social.technet.microsoft.com/Forums/en-US/c4a7cbeb-53fa-492f-b300-9f6b7a0f441f/2012-sp1-dcom-1053?forum=dataprotectionmanager